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Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome
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SYSNO ASEP 0358902 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome Author(s) Pravenec, Michal (FGU-C) RID, ORCID
Kajiya, T. (US)
Zídek, Václav (FGU-C) RID
Landa, Vladimír (FGU-C) RID
Mlejnek, Petr (FGU-C) RID, ORCID
Šimáková, Miroslava (FGU-C) RID, ORCID
Šilhavý, Jan (FGU-C) RID, ORCID
Malínská, H. (CZ)
Oliyarnyk, O. (CZ)
Kazdová, L. (CZ)
Fan, J. (JP)
Wang, J. (US)
Kurtz, T. W. (US)Source Title Hypertension. - : Lippincott Williams & Wilkins - ISSN 0194-911X
Roč. 57, č. 4 (2011), s. 731-737Number of pages 7 s. Language eng - English Country US - United States Keywords C-reactive protein ; metabolic syndrome ; transgenic rat Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects NS9759 GA MZd - Ministry of Health (MZ) ME08006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP301/10/0290 GA ČR - Czech Science Foundation (CSF) GAP303/10/0505 GA ČR - Czech Science Foundation (CSF) IAA500110805 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000288434600019 DOI 10.1161/HYPERTENSIONAHA.110.164350 Annotation We sought to investigate whether increased levels of human CRP, per se, can promote increases in blood pressure and disturbances in glucose and lipid metabolism characteristic of the metabolic syndrome. To accomplish this goal, we transgenically expressed human CRP in the spontaneously hypertensive rat (SHR) and found that that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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