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Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines

SYSNO ASEP	0357898
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines
Author(s)	Gucký, Tomáš (UEB-Q)_ORCID Řezníčková, Eva (UEB-Q)_{RID, ORCID} Džubák, P. (CZ) Hajdúch, M. (CZ) Kryštof, Vladimír (UEB-Q)_{RID, ORCID}
Source Title	Monatshefte fur Chemie. - : Springer - ISSN 0026-9247 Roč. 141, č. 6 (2010), s. 709-714
Number of pages	6 s.
Language	eng - English
Country	AT - Austria
Keywords	Pyrazolo[4,3-e][1,2,4]triazine ; Anticancer ; Cyclin-dependent kinase
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA204/08/0511 GA ČR - Czech Science Foundation (CSF)
	GA301/08/1649 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000278470600016
DOI	10.1007/s00706-010-0314-4
Annotation	The deregulation of cell cycle components in cancer cells has provided a rationale for the development of small molecule inhibitors of cyclin-dependent kinases as novel anticancer drugs. A series of 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines was synthesized and their kinase inhibitory activity and cytotoxicity against several cancer cell lines has been evaluated. Some of the compounds of the series exhibited induction of caspase-dependent cell death and inhibition of cyclin-dependent kinase 2 (CDK2).
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2011

Number of the records: 1