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Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors
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SYSNO ASEP 0357894 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors Author(s) Hyun, T.K. (AT)
Havlíček, Libor (UEB-Q) RID, ORCID
Strnad, Miroslav (UEB-Q) RID, ORCID
Roitsch, T. (AT)Source Title Biosciences Biotechnology and Biochemistry - ISSN 0916-8451
Roč. 74, č. 3 (2010), s. 553-557Number of pages 5 s. Language eng - English Country JP - Japan Keywords mitogen-activated protein kinase (MAPK) ; trisubstituted purines ; inhibitor Subject RIV FD - Oncology ; Hematology R&D Projects GA301/08/1649 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000276541600017 DOI 10.1271/bbb.90743 Annotation A number of compounds have been reported to be specific inhibitors of protein kinases mediated by structural-based selectivity,but the development of specific inhibitors has not yet been addressed in plant science.Here we tested C2,C6,and N9-trisubstituted purines to determine the basic relationship between their chemical structure and inhibitory activity versus a plant mitogen-activated protein kinase (MAPK).Modification of substitution at positions C2 and N9 caused increased inhibitory activity of 6-benzylaminopurine analogs.In the case of 6-isopentenyladenine derivatives, the addition of a methyl group at position N9 caused at least 2-fold increased inhibitory activity, as compared with the addition of an isopropyl group. The data indicate that the selectivity and potency of inhibitors can be improved by modification of the chemical structure, suggesting that trisubstituted purines are powerful tools for probing biological processes and understanding the physiological roles of MAPK signaling. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2011
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