Number of the records: 1

Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway

SYSNO ASEP	0357770
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway
Author(s)	Vondálová Blanářová, Olga (BFU-R) Jelínková, Iva (BFU-R) Szoor, A. (HU) Skender, Belma (BFU-R) Souček, Karel (BFU-R)_{RID, ORCID} Horváth, Viktor (BFU-R) Vaculová, Alena (BFU-R)_{RID, ORCID} Anděra, Ladislav (UMG-J)_RID Sova, P. (CZ) Szollosi, J. (HU) Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Vereb, G. (HU) Kozubík, Alois (BFU-R)_{RID, ORCID}
Number of authors	13
Source Title	Carcinogenesis. - : Oxford University Press - ISSN 0143-3334 Roč. 32, č. 1 (2011), s. 42-51
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	TRAIL ; platinum complexes ; apoptosis
Subject RIV	BO - Biophysics
R&D Projects	GA301/07/1557 GA ČR - Czech Science Foundation (CSF)
	NS9600 GA MZd - Ministry of Health (MZ)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000286303000007
DOI	10.1093/carcin/bgq220
Annotation	Platinum complexes LA-12 and cisplatin enhanced TRAIL-induced apoptosis in colon and prostate cancer cells. They increased surface expression of DR5 receptor for TRAIL, which has been shown to be crucial for induction of apoptosis. Moreover, LA-12 and cisplatin mediated translocation of TRAIL receptors DR4 and DR5 to lipid rafts and enhanced internalization of TRAIL. These events modulated early steps of TRAIL, signaling and may contribute to induction of apoptosis.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1