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Polymeric nanocapsules ultra stable in complex biological media

SYSNO ASEP	0357473
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Polymeric nanocapsules ultra stable in complex biological media
Author(s)	Rodriguez-Emmenegger, Cesar Adolfo (UMCH-V)_RID Jäger, Alessandro (UMCH-V)_{RID, ORCID} Jäger, Eliezer (UMCH-V)_{ORCID, RID} Štěpánek, Petr (UMCH-V)_{RID, ORCID} Bologna Alles, A. (UY) Guterres, S. S. (BR) Pohlmann, A. R. (BR) Brynda, Eduard (UMCH-V)_RID
Source Title	Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765 Roč. 83, č. 2 (2011), s. 376-381
Number of pages	6 s.
Language	eng - English
Country	NL - Netherlands
Keywords	core/shell nanocapsules ; biodegradable ; antifouling coating
Subject RIV	JA - Electronics ; Optoelectronics, Electrical Engineering
R&D Projects	KAN200670701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GAP208/10/1600 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000287268000025
DOI	10.1016/j.colsurfb.2010.12.013
Annotation	Nanocapsules (NC) prepared from FDA-approved degradable poly( -caprolactone) shell and Mygliol 812® oil in the core were coated with oligo(ethylene glycol) methacrylate (poly(MeOEGMA)) polymer brushes with a well-controlled thickness up to 350 nm using surface initiated atom transfer radical polymerization in water or phosphate buffered saline. Incubation of uncoated NC with human serum albumin solution, fetal bovine serum, or human blood plasma resulted in fast aggregation observed by dynamic light scattering as an increase in diameter of particles present in the solutions. Conversely, these biological fluids affected only marginally the size distribution of the NC coated with a 60 nm thick poly(MeOEGMA) layer. The high suspension stability of the coated NC in complex biological fluids was related to the suppressed deposition of proteins from these fluids observed by surface plasmon resonance (SPR) on analogous poly(MeOEGMA) layer prepared on flat surfaces of SPR chips.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2011

Number of the records: 1