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Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity
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SYSNO ASEP 0356878 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity Author(s) Drábiková, K. (SK)
Perečko, T. (SK)
Nosál, R. (SK)
Račková, L. (SK)
Ambrožová, Gabriela (BFU-R) RID
Lojek, Antonín (BFU-R) RID
Šmidrkal, J. (CZ)
Harmatha, Juraj (UOCHB-X) RID, ORCID
Jančinová, V. (SK)Number of authors 9 Source Title Neuroendocrinology Letters - ISSN 0172-780X
Roč. 31, č. 2 (2010), s. 73-78Number of pages 6 s. Language eng - English Country SE - Sweden Keywords reactive species ; phagocytosis ; coumarin Subject RIV BO - Biophysics R&D Projects MEB0810013 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000288061000014 Annotation Synthetic phenylcoumarin derivatives HHC (7-hydroxy-3-(4'-hydroxyphenyl) coumarin) and HHDC (7-hydroxy-3-(4'-hydroxyphenyl)-3,4-dihydrocoumarin) can affect ROS generation in human neutrophils and NO production by RAW 264.7 macrophages. The obtained results highlighted the different effects of HHC and HHDC on fagocyte functions, which might be due to their diverse free radical scavenging properties and lipophilicity features. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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