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CGG repeats associated with fragile X chromosome form left-handed Z-DNA structure

SYSNO ASEP	0356600
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	CGG repeats associated with fragile X chromosome form left-handed Z-DNA structure
Author(s)	Renčiuk, Daniel (BFU-R)_{RID, ORCID} Kypr, Jaroslav (BFU-R)_RID Vorlíčková, Michaela (BFU-R)_{RID, ORCID}
Number of authors	3
Source Title	Biopolymers - ISSN 0006-3525 Roč. 95, č. 3 (2011), s. 174-181
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	fragile X chromosome syndrome ; Z-DNA ; trinucleotide repeats
Subject RIV	BO - Biophysics
R&D Projects	GA202/07/0094 GA ČR - Czech Science Foundation (CSF)
	IAA100040701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000286086500002
DOI	10.1002/bip.21555
Annotation	In this work we demonstrate that CGG runs adopt a left-handed Z-DNA structure and its formation increased with increasing number of repeats. We show here that methylation of the (CGG) runs markedly stabilized Z-DNA formation.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1