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Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death

SYSNO ASEP	0356581
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death
Author(s)	Zuberová, M. (CZ) Fencková, M. (CZ) Šimek, Petr (BC-A)_{RID, ORCID} Janečková, L. (CZ) Doležal, T. (CZ)
Number of authors	5
Source Title	Disease Models & Mechanisms. - : Company of Biologists - ISSN 1754-8403 Roč. 3, 11/12 (2010), s. 773-784
Number of pages	12 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	central nervous system ; glycogen phosphorylase ; immune response
Subject RIV	CE - Biochemistry
R&D Projects	GD204/09/H058 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50070508 - ENTU-I, BC-A (2005-2011)
UT WOS	000284061000021
DOI	10.1242/dmm.005389
Annotation	Extracellular adenosine is an important signaling molecule in neuromodulation, immunomodulation and hypoxia. Adenosine dysregulation can cause various pathologies, exemplified by a deficiency in adenosine deaminase in severe combined immunodeficiency. We have established a Drosophila model to study the effects of increased adenosine in vivo by mutating the main Drosophila adenosine deaminase-related growth factor (ADGF-A). Using a genetic screen, we show here that the increased extracellular adenosine in the adgf-a mutant is associated with hyperglycemia and impairment in energy storage. The adenosine works in this regard through the adenosine receptor as an anti-insulin hormone in parallel to adipokinetic hormone, a glucagon counterpart in flies. If not regulated properly, this action can lead to a loss of energy reserves (wasting) and death of the organism.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2011

Number of the records: 1