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Azacytosine Derivatives Useful as Antiviral Agents
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SYSNO ASEP 0356428 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title Azacytosine Derivatives Useful as Antiviral Agents Author(s) Holý, Antonín (UOCHB-X)
Krečmerová, Marcela (UOCHB-X) RID, ORCID
Pískala, Alois (UOCHB-X)
Andrei, G. (BE)
Snoeck, R. (BE)
De Clercq, E. (BE)
Neyts, J. (BE)
Naesens, L. (BE)Number of authors 8 Year of issue 2010 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. EP1966226 Date of the patent acceptance 10.11.2010 Name of the patent owner Ústav organické chemie a biochemie AV ČR, v. v. i. - K.U. Leuven Research and Development, Leuven, BE Current use B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem Language eng - English Country DE - Germany Keywords 5-azacytosine ; triazine ; antivirals ; acyclic nucleoside phosphonates Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) Annotation 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (HPMP-5-azaC), its cyclic form and a series of ester prodrugs were prepared as a new type of antiviral agents active against all species of DNA viruses in vitro and in vivo. HPMP-5-azaC showed a 2- to 16-fold higher antiviral selectivity index compared to cidofovir. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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