[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with alpha, omega-Diynes

Number of the records: 1

1.

SYSNO ASEP	0356369
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with alpha, omega-Diynes
Author(s)	Opekar, S. (CZ) Turek, P. (CZ) Pohl, Radek (UOCHB-X)_{RID, ORCID} Klepetářová, Blanka (UOCHB-X)_{RID, ORCID} Votruba, Ivan (UOCHB-X)_RID Hocek, Michal (UOCHB-X)_{RID, ORCID} Kotora, M. (CZ)
Number of authors	7
Source Title	Heterocycles. - : Elsevier - ISSN 0385-5414 Roč. 82, č. 1 (2010), s. 895-907
Number of pages	13 s.
Language	eng - English
Country	JP - Japan
Keywords	cyclotrimerization ; purine ; alkyne ; nickel ; catalysis
Subject RIV	CC - Organic Chemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000286906100065
DOI	10.3987/COM-10-S(E)56
Annotation	6-Alkynyl-7-benzylpurines were prepared by the Sonogashira reaction from 6-chloro-7-benzylpurines and terminal alkynes. The prepared alkynylpurines were cyclotrimerized with various 1,6-diynes in the presence of Ni(cod)2/2PPh3 catalytic system into the corresponding 6-aryl-7-benzylpurines under ambient conditions. The prepared 6-alkynyl- and 6-aryl-7-benzylpurines were tested for cytostatic activity.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1