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The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1

SYSNO ASEP	0356171
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
Author(s)	Samad, Abdul (FGU-C) Surá, Lucie (FGU-C) Benedikt, Jan (FGU-C) Ettrich, Rüdiger (UEK-B)_{RID, ORCID, SAI} Minofar, Babak (UEK-B)_RID Teisinger, Jan (FGU-C)_RID Vlachová, Viktorie (FGU-C)_{RID, ORCID, SAI}
Source Title	Biochemical Journal. - : Portland Press - ISSN 0264-6021 Roč. 433, č. 1 (2011), s. 197-204
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	ankyrin receptor ; transient receptor channel ; voltage sensor
Subject RIV	FH - Neurology
R&D Projects	GA305/06/0319 GA ČR - Czech Science Foundation (CSF)
	GAP301/10/1159 GA ČR - Czech Science Foundation (CSF)
	IAA600110701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
	AV0Z60870520 - UEK-B (2005-2011)
UT WOS	000290055700020
DOI	10.1042/BJ20101256
Annotation	The ankyrin transient receptor potential channel TRPA1 is a nonselective cationic channel that is expressed by sensory neurons, where it can be activated by pungent chemicals, such as allyl isothiocyanate (AITC) or highly depolarizing voltages (> +100 mV). In this study, we mutated 27 basic residues all along the C-terminal tail of TRPA1 and explored their role in AITC and voltage-dependent gating. We identify basic residues in the C-terminus that are strongly involved in TRPA1 voltage and chemical sensitivity, some of them may represent possible interaction sites for negatively charged molecules that are generally considered to modulate TRPA1
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1