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Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy
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SYSNO ASEP 0356090 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy Author(s) Záruba, K. (CZ)
Králová, Jarmila (UMG-J) RID
Řezanka, P. (CZ)
Poučková, P. (CZ)
Veverková, L. (CZ)
Král, V. (CZ)Source Title Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
Roč. 8, č. 14 (2010), s. 3202-3206Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords photothermal therapy ; photosensitizers ; agents Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA203/09/1311 GA ČR - Czech Science Foundation (CSF) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000279566700014 DOI 10.1039/c002823a Annotation Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy (PDT) was assayed using the basaloid squamous cell carcinoma PE/CA-PJ34 cell line. In vitro PDT experiments revealed that the gold nanoparticle-bound conjugates were less effective than unbound conjugates in killing cells. However, the same conjugates were more effective in reducing tumor size in vivo, with complete tumor regression observed. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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