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Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis
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SYSNO ASEP 0356081 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis Author(s) Kejík, Z. (CZ)
Bříza, T. (CZ)
Králová, Jarmila (UMG-J) RID
Martásek, P. (CZ)
Král, V. (CZ)Source Title Analytical and Bioanalytical Chemistry. - : Springer - ISSN 1618-2642
Roč. 398, č. 5 (2010), s. 1865-1870Number of pages 6 s. Language eng - English Country DE - Germany Keywords extracellular-matrix components ; hepatocellular carcinoma ; breast cancer Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA203/09/1311 GA ČR - Czech Science Foundation (CSF) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000283244500005 DOI 10.1007/s00216-010-4124-7 Annotation It is well known that saccharides and their glycoconjugates can have an important influence on various serious pathologic stages such as cancer. They can regulate tumor proliferation, invasion, hematogenous metastasis, and angiogenesis. These facts clearly show the importance of cancer saccharide recognition. In medicine, sensor analysis is one of the best methods for recognition and determination of biologically important analytes. The development and study of sensors for saccharide tumor markers can open a new way for their detection. Therefore, this review is focused on recognition of saccharide-based cancer markers by natural or synthetic selective ligands working as bio- and chemosensors. The design and application of these ligands for cancer diagnosis is a useful direction of research. Moreover, it also opens the possibility of using these agents for the targeted drug transport required for advanced anticancer therapy. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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