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Loss of the response regulator CtrA causes pleiotropic effects on gene expression but does not affect growth phase regulation in Rhodobacter capsulatus

SYSNO ASEP	0356033
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Loss of the response regulator CtrA causes pleiotropic effects on gene expression but does not affect growth phase regulation in Rhodobacter capsulatus
Author(s)	Mercer, R.G. (CA) Callister, S.J. (US) Lipton, M.S. (US) Pasa-Tolic, L. (US) Strnad, Hynek (UMG-J)_RID Pačes, Václav (UMG-J)_RID Beatty, J.T. (CA) Lang, A.S. (CA)
Source Title	Journal of Bacteriology. - : American Society for Microbiology - ISSN 0021-9193 Roč. 192, č. 11 (2010), s. 2701-2710
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	Gene transfer agent ; ctrA regulator protein ; gene expression
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000277549300005
DOI	10.1128/JB.00160-10
Annotation	The CtrA protein in Caulobacter crescentus has been thoroughly studied for its role as an essential, master regulator of the cell cycle. Although the CtrA protein in R. capsulatus shares a high degree of sequence similarity with the C. crescentus protein, it is nonessential and clearly plays a different role in this bacterium. We have used transcriptomic and proteomic analyses of wild-type and ctrA mutant cultures to identify the genes dysregulated by the loss of CtrA in R. capsulatus. We have also characterized gene expression differences between the logarithmic and stationary phases of growth. Loss of CtrA has pleiotropic effects, with dysregulation of expression of approximately 6% of genes in the R. capsulatus genome.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2011

Number of the records: 1