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Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning
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SYSNO ASEP 0355826 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning Author(s) Kozmiková, Iryna (UMG-J) RID
Smolíková, Jana (UMG-J) RID
Vlček, Čestmír (UMG-J) RID
Kozmik, Zbyněk (UMG-J) RIDSource Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 2 (2011), e14650Number of pages 21 s. Language eng - English Country US - United States Keywords Wnt Bmp ; amphioxus ; axial patterning Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500520604 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA500520908 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000287036600003 DOI 10.1371/journal.pone.0014650 Annotation Formation of a dorsoventral axis is a key event in the early development of most animal embryos. It is well established that bone morphogenetic proteins (Bmps) and Wnts are key mediators of dorsoventral patterning in vertebrates. In the cephalochordate amphioxus, genes encoding Bmps and transcription factors downstream of Bmp signaling such as Vent are expressed in patterns reminiscent of those of their vertebrate orthologues. We found that Bmp but not canonical Wnt signaling regulates promoters of genes encoding homeodomain proteins AmphiVent1 and AmphiVent2. Our data indicate high evolutionary conservation of a core Bmp-triggered gene regulatory network for dorsoventral patterning in chordates and suggest that co-option of the canonical Wnt signaling pathway for dorsoventral patterning in vertebrates represents one of the innovations through which an increased morphological complexity of vertebrate embryo is achieved. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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