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STIM1-Directed Reorganization of Microtubules in Activated Mast Cells
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SYSNO ASEP 0355825 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title STIM1-Directed Reorganization of Microtubules in Activated Mast Cells Author(s) Hájková, Zuzana (UMG-J)
Bugajev, Viktor (UMG-J) RID
Dráberová, Eduarda (UMG-J) RID, ORCID
Vinopal, Stanislav (UMG-J)
Dráberová, Lubica (UMG-J) RID
Janáček, Jiří (FGU-C) RID, ORCID
Dráber, Petr (UMG-J) RID
Dráber, Pavel (UMG-J) RID, ORCIDSource Title Journal of Immunology. - : American Association of Immunologists - ISSN 0022-1767
Roč. 186, č. 2 (2011), s. 913-923Number of pages 11 s. Language eng - English Country US - United States Keywords STIM1 ; bonemarrow-derived mast cells ; microtubules Subject RIV EB - Genetics ; Molecular Biology R&D Projects GD204/09/H084 GA ČR - Czech Science Foundation (CSF) GA204/09/1777 GA ČR - Czech Science Foundation (CSF) GA301/09/1826 GA ČR - Czech Science Foundation (CSF) GAP302/10/1759 GA ČR - Czech Science Foundation (CSF) LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) KAN200520701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000285917700030 DOI 10.4049/jimmunol.1002074 Annotation This research article shows important role of STIM1 protein in activation of bone marrow-derived mast cells. During activation process, mast cells change intracellular level of calcium and present microtubule reorganization. The molecular mechanisms for control microtubule rearrangement during activation events are still unknown. Activation of mast cells results in generation of microtubule protrusions that are calcium dependent. Experiments with knockdown or reexpression of STIM1 protein, the key regulator of store-operated calcium entry, confirmed the important role of STIM1 in the formation of protrusions. This article propose that calcium plays an important role in the formation of microtubule protrusions in mast cells and that rearrangement of microtubules in activated mast cells depends on STIM1-induced calcium entry. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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