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Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation

SYSNO ASEP	0355817
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation
Author(s)	Philimonenko, Anatoly (UMG-J) Janáček, Jiří (FGU-C)_{RID, ORCID} Snyers, L. (AT) Almeder, M. (AT) Berger, W. (AT) Schmidt, W. (AT) Schofer, C. (AT) Hozák, Pavel (UMG-J)_{RID, ORCID}
Source Title	Journal of Structural Biology. - : Elsevier - ISSN 1047-8477 Roč. 173, č. 2 (2011), s. 382-390
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	Chromosome territory ; Gene expression ; Confocal imaging
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	2B06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50520514 - UMG-J (2005-2011)
	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000286846700021
DOI	10.1016/j.jsb.2010.10.010
Annotation	In this study we analyzed the position of the cell cycle regulator gene p21 within the CT of human chromosome 6 (HSA6) upon transcriptional activation. Whereas the majority of active p21 genes is located in the interior of the CT of HSA6, induction of p21 transcription correlates with increased variation of gene localization within the CT and with a higher percentage of p21 genes located at the periphery of the CT. Additionally it demonstrates once more that transcription can take place throughout CTs. Comparison of the p21 locus with two non-coding regions on HSA6 showed that both non-coding sequences are located more frequently in the interior of the CT than p21 genes although they are situated in chromosomal neighborhoods with widely differing gene density and regional transcriptional activity. Thus our data support models describing an influence of the transcriptional activity of a gene on the localization within its CT.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2011

Number of the records: 1