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Dispersal kinetics of deuterated water in the lungs and airways following mouth inhalation: real-time breath analysis by flowing afterglow mass spectrometry (FA-MS)
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SYSNO ASEP 0355626 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dispersal kinetics of deuterated water in the lungs and airways following mouth inhalation: real-time breath analysis by flowing afterglow mass spectrometry (FA-MS) Author(s) Tan, B. K. (GB)
Smith, D. (GB)
Španěl, Patrik (UFCH-W) RID, ORCID
Davies, S. J. (GB)Source Title Journal of Breath Research. - : Institute of Physics Publishing - ISSN 1752-7155
Roč. 4, č. 1 (2010), 017109Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords mass spectrometry ; breath analysis ; pulmonary-edema Subject RIV CF - Physical ; Theoretical Chemistry CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000283129400013 DOI 10.1088/1752-7155/4/1/017109 Annotation Pulmonary oedema is a medical condition characterized by abnormal accumulation of fluid in the extravascular space in the alveoli. Effective oxygenation is impaired and this leads to significant short-and long-term morbidity and mortality. The detection and monitoring of pulmonary oedema by measuring lung water volume is therefore crucial in the initiation and guidance of therapeutic intervention. The current gold standard bedside measurement of extravascular lung water volume (EVLW) is the dilution method using various indicators, but despite the good correlation of the results with those obtained using the post-mortem gravimetric method, the invasiveness of the dilution technique limits its general application in the wider clinical setting. In the present preliminary experiments, the dispersal kinetics of deuterium in exhaled breath of three healthy participants following the inhalation of deuterium oxide vapour are explored as monitored using flowing afterglow mass spectrometry. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2011
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