Number of the records: 1

Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase

SYSNO ASEP	0355550
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase
Author(s)	Nůsková, Hana (FGU-C)_{RID, ORCID} Vrbacký, Marek (FGU-C)_{RID, ORCID} Drahota, Zdeněk (FGU-C)_{RID, ORCID} Houštěk, Josef (FGU-C)_{RID, ORCID}
Source Title	Journal of Bioenergetics and Biomembranes - ISSN 0145-479X Roč. 42, č. 5 (2010), s. 395-403
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	cytochrom c oxidase ; cyanide ; oxygen affinity
Subject RIV	CE - Biochemistry
R&D Projects	GA303/07/0781 GA ČR - Czech Science Foundation (CSF)
	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000284603500006
DOI	10.1007/s10863-010-9307-6
Annotation	Analysis of the mechanism of cyanide inhibitory effect on the mitochondrial cytochrome c oxidase demonstrates that the inhibition of COX by cyanide is fully reversible but the potential of pyruvate as a cyanide poisoning antidote is limited. COX affinity for oxygen is the most sensitive indicator of cyanide toxic effects
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1