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Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats
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SYSNO ASEP 0355370 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats Author(s) Bubeníková-Valešová, V. (CZ)
Svoboda, Jan (FGU-C) RID, ORCID
Horáček, J. (CZ)
Sumiyoshi, T. (JP)Source Title Psychopharmacology. - : Springer - ISSN 0033-3158
Roč. 212, č. 2 (2010), s. 267-276Number of pages 10 s. Language eng - English Country US - United States Keywords Tandospirone ; Schizophrenia ; NMDA receptor Subject RIV FH - Neurology R&D Projects 1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000281740400013 DOI 10.1007/s00213-010-1951-3 Annotation These findings suggest that behavioural changes induced by tandospirone are not fully blocked by 5-HT1A antagonists and that tandospirone (5 mg/kg) potentiates the effect of MK-801. Overall, these findings point to an interaction between NMDA and 5-HT(1A) receptors. Part of the effect of tandospirone on locomotor activity may be mediated by the actions of its active metabolites on other neurotransmitter systems Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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