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Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model
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SYSNO ASEP 0355310 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Author(s) Lenčová, Anna (UMG-J)
Pokorná, Kateřina (UMG-J)
Zajícová, Alena (UMG-J)
Krulová, Magdalena (UMG-J)
Filipec, M. (CZ)
Holáň, Vladimír (UMG-J)Source Title Transplant Immunology. - : Elsevier - ISSN 0966-3274
Roč. 24, č. 3 (2011), s. 189-194Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords limbal transplantation ; graft survival ; cytokine response Subject RIV EC - Immunology R&D Projects KAN200520804 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000288478500008 DOI 10.1016/j.trim.2010.11.005 Annotation A new model of orthotopic limbal transplantation was established in the mouse. The survival of limbal autografts, allografts and xenografts was characterized according to the clinical criteria, and intragraft cytokine response was determined by a real-time PCR. The results showed that the limbal grafts do not enjoy immune privilege of the eye and are promptly rejected by Th1 or combined Th1 and Th2 type of immune response involving CD4 pozitive cells and iNOS expression. Targeting this pathway may be an effective way to prevent and treat limbal graft rejection. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2012
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