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The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
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SYSNO ASEP 0355121 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of the tissue microenvironment in the regulation of cancer cell motility and invasion Author(s) Brabek, J. (CZ)
Mierke, C.T. (DE)
Rosel, D. (CZ)
Veselý, Pavel (UMG-J)
Fabry, B. (DE)Source Title Cell communication and signaling : CCS
Roč. 8, č. 22 (2010), 22e-22eNumber of pages 8 s. Language eng - English Country GB - United Kingdom Keywords endothelial barrier function ; pericellular proteolysis ; melanoma cells Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC06061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000282265700003 DOI 10.1186/1478-811X-8-22. Annotation During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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