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NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

SYSNO ASEP	0355110
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours
Author(s)	Indrová, Marie (UMG-J)_RID Šímová, Jana (UMG-J)_RID Bieblová, Jana (UMG-J) Bubeník, Jan (UMG-J) Reiniš, Milan (UMG-J)_RID
Source Title	Oncology Reports - ISSN 1021-335X Roč. 25, č. 1 (2011), s. 281-288
Number of pages	8 s.
Language	eng - English
Country	GR - Greece
Keywords	MHC class I-deficient tumours ; CD8+, CD4+, NK1.1+cell subpopulations ; interferon gamma
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	IAA500520807 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000286303800038
DOI	10.3892/or_00001072
Annotation	In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells..
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2011

Number of the records: 1