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Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP

SYSNO ASEP	0354978
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP
Author(s)	Medvedev, N. I. (GB) Popov, V. I. (GB) Dallerac, G. (FR) Davies, H.A. (GB) Laroche, S. (FR) Kraev, I. V. (GB) Rodríguez Arellano, Jose Julio (UEM-P) Doyere, V. (FR) Stewart, M.G. (GB)
Source Title	Neuroscience. - : Elsevier - ISSN 0306-4522 Roč. 171, č. 2 (2010), s. 390-397
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	D synaptic ultrastructure ; hippocampus ; long term potentiation and depression
Subject RIV	FH - Neurology
CEZ	AV0Z50390703 - UEM-P (2007-2013)
UT WOS	000284194000004
DOI	10.1016/j.neuroscience.2010.09.014
Annotation	Alterations in curvature of the post synaptic density (PSD) and apposition zone (AZ), are believed to play an important role in determining synaptic efficacy. In the present study we have examined curvature of PSDs and AZs 24 h following homosynaptic long-term potentiation (LTP), and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats.Very large and significant changes in 3-D measurements of AZ and PSD curvature occurred 24 h following both LTP and LTD, with a flattening of the normal concavity of mushroom spine heads and a change to convexity for thin spines.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2011

Number of the records: 1