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Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic

SYSNO ASEP	0354964
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic
Author(s)	Pratt, M. M. (US) King, L. C. (US) Adams, L. D. (US) John, K. (US) Sirajuddin, P. (US) Olivero, O. A. (US) Manchester, D. K. (US) Šrám, Radim (UEM-P)_RID DeMarini, D. M. (US) Poirier, M. C. (US)
Source Title	Environmental and Molecular Mutagenesis. - : Wiley - ISSN 0893-6692 Roč. 52, č. 1 (2011), s. 58-68
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	automated cellular imaging system ; immunohistochemistry ; BPDE-DNA antiserum
Subject RIV	DN - Health Impact of the Environment Quality
R&D Projects	SP/1B3/8/08 GA MŽP - Ministry of Environment (MŽP)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000286784500008
EID SCOPUS	78651102556
DOI	10.1002/em.20581
Annotation	Three classes of DNA damage were assessed in human placentas collected (2000-2004) from 51 women from the Teplice region, Czech Rep. More generalized DNA damage was measured both by 32P-postlabelling and by abasic (AB) site analysis. For both methods, there was no correlation among types of DNA damage and no difference in the extent of DNA damage between smokers and nonsmokers. The data show that DNA from placentas obtained in Teplice contained multiple types of DNA damage, which likely arose from various environmental exposures.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2011

Number of the records: 1