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Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart
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SYSNO ASEP 0354866 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart Author(s) Hlaváčková, M. (CZ)
Kožichová, K. (CZ)
Neckář, Jan (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAI
Musters, R.J.P. (NL)
Novák, O. (CZ)
Nováková, O. (CZ)Source Title Molecular and Cellular Biochemistry. - : Springer - ISSN 0300-8177
Roč. 345, 1-2 (2010), s. 271-282Number of pages 12 s. Language eng - English Country US - United States Keywords protein kinase C ; chronic intermittent hypoxia ; heart Subject RIV ED - Physiology R&D Projects GA305/07/0875 GA ČR - Czech Science Foundation (CSF) 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000284907100029 DOI 10.1007/s11010-010-0581-8 Annotation The aim of the study was to examine the effects of chronic intermittent hypoxia (CIH) and acute administration of PKC-delta inhibitor rottlerin on the expression and subcellular distribution of PKC-delta and PKC-epsilon in the left ventricular myocardium in rats. It has been shown that CIH up-regulated PKC-delta which was localized to mitochondrial and sarcolemmal membranes. The inhibitory effects of rottlerin on PKC-delta subcellular redistribution and cardioprotection (as shown previously) support the view that this isoform plays a role in the mechanism of CIH-induced ischemic tolerance Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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