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The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level

SYSNO ASEP	0354704
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level
Title	Úloha TRPV1 endogenního agonisty N-oleoyldopaminu v modulaci nociceptivní signalizace na míšní úrovni
Author(s)	Špicarová, Diana (FGU-C)_{RID, ORCID} Paleček, Jiří (FGU-C)_{RID, ORCID}
Source Title	Journal of Neurophysiology - ISSN 0022-3077 Roč. 102, č. 1 (2009), s. 234-243
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	pain ; TRPV1 ; spinal cord
Subject RIV	FH - Neurology
R&D Projects	GA305/09/1228 GA ČR - Czech Science Foundation (CSF)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA305/06/1115 GA ČR - Czech Science Foundation (CSF)
UT WOS	267446000023
DOI	10.1152/jn.00024.2009
Annotation	OLDA application in acute spinal cord slices leads to significant increase of AMPA mediated mEPSC frequency in high concentration. After PKC activation or under pathological conditions only low concentration is needed. Presynaptic spinal cord TRPV1 receptors have a significant modulatory role in nociceptive signalling and may be activated by low concentrations of endogenous agonists like OLDA under pathological conditions
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1