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To suppress to rescue? Changing the approach for recalling anticancer immune responses

SYSNO ASEP	0354370
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	To suppress to rescue? Changing the approach for recalling anticancer immune responses
Author(s)	Vannucci, Luca (MBU-M)_{RID, ORCID}
Source Title	Front Biosci (Schol Ed) - ISSN 1945-0516 -, č. 2 (2010), s. 1189-1197
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	inflammmation ; cancer ; immunity
Subject RIV	EC - Immunology
R&D Projects	IAA500200917 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
Annotation	The tumor microenvironment plays a fundamental role in influencing the anticancer immune response. Recent experimental anticancer therapy show that some anticancer chemotherapeutics can improve tumor control by acting on immunity and can also be used in immunosuppressive treatments. On the base of current inflammatory cancer microenvironment model, we suggest recovering the anticancer response by paradoxically inducing a temporary immune suppression. In this paper, we review present concepts about inflammation and immunity in the cancer microenvironment, as well as experimental data from recent literature supporting this paradoxical intervention hypothesis
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1