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Molecular mass spectrometry imaging in biomedical and life science research
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SYSNO ASEP 0354266 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Molecular mass spectrometry imaging in biomedical and life science research Author(s) Pól, Jaroslav (MBU-M)
Strohalm, Martin (MBU-M)
Havlíček, Vladimír (MBU-M) RID, ORCID
Volný, Michael (MBU-M) ORCIDSource Title Histochemistry and Cell Biology. - : Springer - ISSN 0948-6143
Roč. 134, č. 5 (2010), s. 423-443Number of pages 21 s. Language eng - English Country DE - Germany Keywords Mass spectrometry ; Chemical imaging ; Molecular imaging Subject RIV EE - Microbiology, Virology R&D Projects LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GPP206/10/P018 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000284070700001 DOI 10.1007/s00418-010-0753-3 Annotation This review describes the current state of mass spectrometry imaging (MSI) in life sciences. A brief overview of mass spectrometry principles is presented followed by a thorough introduction to the MSI workflows, principles and areas of application. Three major desorptionionization techniques used in MSI, namely, secondary ion mass spectrometry (SIMS), matrix-assisted laser desorption ionization (MALDI), and desorption electrospray ionization (DESI) are described, and biomedical and life science imaging applications of each ionization technique are reviewed. A separate section is devoted to data handling and current challenges and future perspectives are briefly discussed at the end Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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