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Integrated liquid chromatography–heated nebulizer microchip for mass spectrometry
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SYSNO ASEP 0354131 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Integrated liquid chromatography–heated nebulizer microchip for mass spectrometry Author(s) Haapala, M. (FI)
Saarela, V. (FI)
Pól, Jaroslav (MBU-M)
Kolari, K. (FI)
Kotiaho, T. (FI)
Franssila, S. (FI)
Kostiainen, R. (FI)Source Title Analytica Chimica Acta. - : Elsevier - ISSN 0003-2670
Roč. 662, č. 2 (2010), s. 163-169Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords Liquid chromatography ; Mass spectrometry ; Microchip Subject RIV CB - Analytical Chemistry, Separation CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000275340600006 DOI 10.1016/j.aca.2010.01.005 Annotation A new integrated microchip for liquid chromatography–mass spectrometry (LC–MS) is presented. The chip is made from bonded silicon and glass wafers with structures for a packed LC column channel, a micropillar frit, a channel for optional optical detection, and a heated vaporizer section etched in silicon and platinum heater elements on the glass cover. LC eluent is vaporized and mixed with nebulizer gas in the vaporizer section and the vapor is sprayed out from the chip. Nonpolar and polar analytes can be efficiently ionized in the gas phase by atmospheric pressure photoionization (APPI) as demonstrated with polycyclic aromatic hydrocarbons (PAHs) and selective androgen receptor modulators (SARMs). This is not achievable with present LC–MS chips, since they are based on electrospray ionization, which is not able to ionize nonpolar compounds efficiently Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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