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Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension

SYSNO ASEP	0353982
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension
Author(s)	Hojná, Silvie (FGU-C)_{RID, ORCID} Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 59, č. 6 (2010), s. 997-1009
Number of pages	13 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	brainstem ; diencephalon ; kidney
Subject RIV	ED - Physiology
R&D Projects	1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA305/08/0139 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000285711400018
Annotation	Our study evaluated NO synthase (NOS) activity and protein expression of its three isoforms - neuronal (nNOS), endothelial NOS (eNOS) and inducible (iNOS) - in two brain regions involved in blood pressure control (diencephalon and brainstem) as well as in the kidney of rats with either genetic (SHR) or salt-induced hypertension (Dahl rats). We disclosed similar changes of NO system in the brainstem (but not in the diencephalon) of rats with genetic and salt-induced hypertension. Decreased nNOS expression was associated with increased blood pressure due to enhanced sympathetic tone
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1