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Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables
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SYSNO ASEP 0353971 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables Author(s) Holland, N. (US)
Fucic, A. (SI)
Merlo, D.F. (IT)
Šrám, Radim (UEM-P) RID
Kirsch-Volders, M. (BE)Source Title Mutagenesis. - : Oxford University Press - ISSN 0267-8357
Roč. 26, č. 1 (2011), s. 51-56Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords Micronucleus assay ; newborns ; children Subject RIV DN - Health Impact of the Environment Quality R&D Projects SP/1B3/8/08 GA MŽP - Ministry of Environment (MŽP) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000285627700008 DOI 10.1093/mutage/geq064 Annotation This is an overview of the micronucleus (MN) assay in lymphocytes and exfoliated epithelial cells of children from birth to adolescence. The article briefly describes the effect of age and sex in different cell types, the use of the MN assay for monitoring of environmental exposures and characterisation of MN levels in children with various diseases and their treatment. The relationship of MN as biomarkers of genotoxicity with other markers, such as genetic polymorphisms and gene expression is also discussed. In the last section, an attempt was made to summarize the current state of knowledge and significant achievements in genotoxicity research in children. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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