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Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro

SYSNO ASEP	0353781
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro
Author(s)	Kostrhunová, Hana (BFU-R)_{RID, ORCID} Vrána, Oldřich (BFU-R)_RID Suchánková, T. (CZ) Gibson, D. (IL) Kašpárková, Jana (BFU-R)_{RID, ORCID} Brabec, Viktor (BFU-R)_{RID, ORCID}
Number of authors	6
Source Title	Chemical Research in Toxicology - ISSN 0893-228X Roč. 23, č. 11 (2010), s. 1833-1842
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	JM118 ; DNA bending ; DNA-protein cross-linking
Subject RIV	BO - Biophysics
R&D Projects	ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ME10066 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GAP301/10/0598 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000284290500023
DOI	10.1021/tx1002904
Annotation	JM118 is the major metabolite of satraplatin. The results of DNA-protein cross-linking assay and DNA repair synthesis by cell-free extract showed a higher DNA-protein cross-linking efficiency of JM118 and less efficient removal from DNA of the adducts of JM118 in comparison with cisplatin.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1