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Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione

SYSNO ASEP	0353777
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
Author(s)	Kostrhunová, Hana (BFU-R)_{RID, ORCID} Kašpárková, Jana (BFU-R)_{RID, ORCID} Gibson, D. (IL) Brabec, Viktor (BFU-R)_{RID, ORCID}
Number of authors	4
Source Title	Molecular Pharmaceutics. - : American Chemical Society - ISSN 1543-8384 Roč. 7, č. 6 (2010), s. 2093-2102
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	JM118 ; cellular accumulation ; glutathione
Subject RIV	BO - Biophysics
R&D Projects	ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ME10066 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GAP301/10/0598 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000284865900020
DOI	10.1021/mp100080e
Annotation	The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1