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HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes
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SYSNO ASEP 0353449 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes Author(s) Hodný, Zdeněk (UMG-J) RID
Mistrik, M. (CZ)
Bártek, Jiří (UMG-J) RIDSource Title Cell Cycle. - : Taylor & Francis - ISSN 1538-4101
Roč. 9, č. 7 (2010), s. 1227-1228Number of pages 2 s. Language eng - English Country US - United States Keywords DNA damage response ; HERC2 ; ubiquitylation Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/08/0353 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000276369300004 DOI 10.4161/cc.9.7.11411 Annotation Targeting of proteins to DNA double strand breaks is highly organized hierarchical process, which depends on posttranslational modifications such as phosphorylation, ubiquitylation and sumoylation. This short review summarizes newly discovered role of protein HERC2, which is targeted to DNA double strand breaks by ATM kinase mediated phosphorylation, where it serves as adaptor protein for ubiquitylation enzymes E3 ligases RNF8 and RNF168 and specifity factor for E2 ligase UBC13. Possible relationship of HERC2 genetic alterations to some human diseases is also discussed. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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