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Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl) -propyl]-4 (S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22

SYSNO ASEP	0352907
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl) -propyl]-4 (S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22
Author(s)	Kyslíková, Eva (MBU-M) Babiak, P. (CZ) Marešová, Helena (MBU-M)_{RID, ORCID} Palyzová, Andrea (MBU-M)_{RID, ORCID} Hajíček, J. (CZ) Kyslík, Pavel (MBU-M)_{RID, ORCID}
Source Title	Journal of Molecular Catalysis B-Enzymatic. - : Elsevier - ISSN 1381-1177 Roč. 67, 3-4 (2010), s. 266-270
Number of pages	5 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Biotransformation ; Rhodococcus fascians MO22 ; Ezetimibe
Subject RIV	CE - Biochemistry
R&D Projects	2B08064 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000284566200017
DOI	10.1016/j.molcatb.2010.09.006
Annotation	Catalytic capability of Rhodococcus fascians MO22 for reduction has been examined with ketone and protected ketone, an intermediate from chemical synthesis of Ezetimibe. Various parameters of the bioreduction have been optimized: the strain converted 94.8 percent of ketone and 63 percent of protected ketone into Ezetimibe with the same de of 99.9 percent. In the later case, two chemical steps are replaced with a single biotransformation
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1