Number of the records: 1
A short survey on protein blocks
- 1.
SYSNO ASEP 0352274 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title A short survey on protein blocks Author(s) Joseph, A.P. (FR)
Agarwal, G. (IN)
Mahajan, S. (IN)
Gelly, J.Ch. (FR)
Swapna, L.S. (IN)
Offmann, B. (CZ)
Cadet, F. (FR)
Bornot, A. (FR)
Tyagi, M. (US)
Valadié, H. (FR)
Schneider, Bohdan (BTO-N) RID, ORCID
Etchebest, C. (FR)
Srinivasan, N. (IN)
de Brevern, A.G. (FR)Source Title Biophysical reviews - ISSN 1867-2450
Roč. 2, č. 3 (2010), s. 137-147Number of pages 11 s. Language eng - English Country DE - Germany Keywords Protein ; bioinformatics ; structure Subject RIV BO - Biophysics CEZ AV0Z50520701 - BTO-N (2007-2013) Annotation Protein structures are classically described in terms of secondary structures. The regular secondary structures have relevant physical meaning but their recognition based on atomic coordinates has a number of limitations, such as uncertainties in the assignment of the boundaries of the helical and strand regions. Moreover, an average of about 50% of all residues are assigned to an irregular state, i.e., the coil. These limitations have led different research teams to focus on abstracting the conformation of the protein backbone in the localized short stretches and different geometric measures are being used to cluster local stretches in protein structures. These libraries of local structure prototypes are named structural alphabets. We have developed a structural alphabet, denoted protein blocks, not only to approximate the protein structures but also to predict them from the sequence. Here, we review some of the most interesting applications of this structural alphabet. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
Number of the records: 1