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Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
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SYSNO ASEP 0351889 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes Author(s) Bébarová, M. (CZ)
Matejovič, P. (CZ)
Pásek, Michal (UT-L) RID, ORCID
Ohlídalová, D. (CZ)
Jansová, D. (CZ)
Šimurdová, M. (CZ)
Šimurda, J. (CZ)Number of authors 7 Source Title Acta Physiologica. - : Wiley - ISSN 1748-1708
Roč. 200, č. 4 (2010), s. 301-314Number of pages 14 s. Language eng - English Country SE - Sweden Keywords action potential ; ethanol ; rat ventricular myocyte Subject RIV BO - Biophysics CEZ AV0Z20760514 - UT-L (2005-2011) UT WOS 000284810500002 DOI 10.1111/j.1748-1716.2010.02162.x Annotation Ethanol belongs to the group of agents that significantly affect the function of cardiac myocytes. The results of performed experiments showed that ethanol reversibly decelerates the upstroke velocity of action potential and decreases its amplitude and duration. Further exploration of the effect of ethanol on membrane ionic currents showed, that ethanol efficiently suppresses INa, ICa and Ito with 50% inhibition at 446 mM, 553 mM a 1954 mM, respectively. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2011
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