Number of the records: 1

Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation

SYSNO ASEP	0351847
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation
Author(s)	Rampichová, Michala (UEM-P)_{RID, ORCID} Filová, Eva (UEM-P)_{RID, ORCID} Varga, F. (CZ) Lytvynets, Andriy (UEM-P) Prosecká, Eva (UEM-P) Koláčná, Lucie (UEM-P) Motlík, Jan (UZFG-Y)_{RID, ORCID} Nečas, A. (CZ) Vajner, L. (CZ) Uhlík, J. (CZ) Amler, Evžen (UEM-P)_RID
Source Title	Asaio Journal - ISSN 1058-2916 Roč. 56, č. 6 (2010), s. 563-568
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	chondrocyte ; composite scaffold ; osteochondral defect regeneration
Subject RIV	BO - Biophysics
R&D Projects	GAP304/10/1307 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
	AV0Z50390703 - UEM-P (2007-2013)
	AV0Z50450515 - UZFG-Y (2005-2011)
UT WOS	000283719600014
DOI	10.1097/MAT.0b013e3181fcbe24
Annotation	Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP).
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2011

Number of the records: 1