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Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
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SYSNO ASEP 0351844 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte Author(s) Ohlidalova, D. (CZ)
Pásek, Michal (UT-L) RID, ORCID
Šimurda, J. (CZ)
Christé, G. (FR)Number of authors 4 Source Title Analysis of biomedical signals and images. - Brno : University of technology, 2010 - ISSN 1211-412X - ISBN 978-80-214-4106-4 Pages s. 114-117 Number of pages 4 s. Publication form CD-ROM - CD-ROM Action BIOSIGNAL Event date 27.06.2010-29.06.2010 VEvent location Brno Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords cardiac cell ; transverse-axial tubular system ; quantitative model Subject RIV BO - Biophysics CEZ AV0Z20760514 - UT-L (2005-2011) Annotation A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2011
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