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Clinical adenoviral gene therapy for prostate cancer
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SYSNO ASEP 0351752 Document Type J - Journal Article R&D Document Type The record was not marked in the RIV Subsidiary J Článek ve WOS Title Clinical adenoviral gene therapy for prostate cancer Author(s) Schenk, E. (NL)
Essand, M. (SE)
Bangma, Ch. H. (NL)
Barber, Ch. (GB)
Behr, J.-P. (FR)
Briggs, S. (GB)
Carlisle, R. (GB)
Cheng, W.-S. (SE)
Danielsson, A. (SE)
Dautzenberg, I. J. C. (NL)
Dzojic, H. (SE)
Erbacher, P. (FR)
Fisher, K. (GB)
Frazier, A. (GB)
Georgopoulos, L. J. (GB)
Hoeben, R. (NL)
Kochanek, S. (DE)
Koppers-Lalic, D. (NL)
Kraaij, R. (NL)
Kreppel, F. (DE)
Lindholm, L. (SE)
Magnusson, M. (SE)
Maitland, N. (GB)
Neuberg, P. (GB)
Nilsson, B. (SE)
Ogris, M. (DE)
Remy, J.-S. (FR)
Scaife, M. (GB)
Schooten, E. (NL)
Seymour, L. (SE)
Totterman, T. (SE)
Uil, T. G. (NL)
Ulbrich, Karel (UMCH-V) RID
Veldhoven-Zweistra, J. L. M. (NL)
de Vrij, J. (NL)
van Weerden, W. (NL)
Wagner, E. (DE)
Willemsen, R. (NL)Source Title Human Gene Therapy. - : Mary Ann Liebert - ISSN 1043-0342
Roč. 21, č. 7 (2010), s. 807-813Number of pages 7 s. Language eng - English Country US - United States Keywords adenovirus ; gene delivery ; prostate cancer Subject RIV CD - Macromolecular Chemistry UT WOS 000279596700003 DOI 10.1089/hum.2009.206 Annotation Prostate cancer is at present the most common malignancy in men in the Western world. When localized, this disease can be treated by curative therapy such as surgery and radiotherapy. Unfortunately, for advanced stage of the disease only palliative treatment is available. Therefore, there is a clinical need for new treatment modalities that can, on the one hand, enhance the cure rate of primary therapy for localized prostate cancer and, on the other hand, improve the treatment of metastasized disease. Gene therapy is now being explored in the clinic as a treatment option for the various stages of prostate cancer. Current clinical experiences are based predominantly on trials with adenoviral vectors. As the first of a trilogy of reviews on the state of the art and future prospects of gene therapy in prostate cancer, this review focuses on the clinical experiences and progress of adenovirus-mediated gene therapy for this disease. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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