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Determination of acid-base dissociation constants of very weak zwitterionic heterocyclic bases by capillary zone electrophoresis

SYSNO ASEP	0351530
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Determination of acid-base dissociation constants of very weak zwitterionic heterocyclic bases by capillary zone electrophoresis
Author(s)	Ehala, Sille (UOCHB-X)_{RID, ORCID} Grishina, Anastasia (UOCHB-X)_RID Sheshenev, Andrey (UOCHB-X) Lyapkalo, Ilya (UOCHB-X) Kašička, Václav (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Journal of Chromatography A. - : Elsevier - ISSN 0021-9673 Roč. 1217, - (2010), s. 8048-8053
Number of pages	6 s.
Language	eng - English
Country	NL - Netherlands
Keywords	acidity constant ; capillary zone electrophoresis ; zwitterionic heterocyclic bases
Subject RIV	CC - Organic Chemistry
R&D Projects	GA203/08/1428 GA ČR - Czech Science Foundation (CSF)
	GA203/09/0675 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000285429700016
DOI	10.1016/j.chroma.2010.08.077
Annotation	Thermodynamic acid-base dissociation (ionization) constants (pKa) of seven very weak zwitterionic heterocyclic bases, originally designed as chiral Lewis base catalysts for enantioselective reactions, were determined by capillary zone electrophoresis (CZE). The pKa values of these compounds were found to be particularly low, in the range 0.04-0.32. Moreover, from the pH dependence of effective mobility of the bases, some other relevant characteristics, such as actual and absolute ionic mobilities and hydrodynamic radii of the acidic cationic forms of the bases were determined.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1