Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation

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SYSNO ASEP	0351524
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation
Author(s)	Vohradský, Jiří (MBU-M)_{RID, ORCID} Pánek, Josef (MBU-M)_RID Vomastek, Tomáš (MBU-M)_{RID, ORCID}
Source Title	Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048 Roč. 38, č. 14 (2010), s. 4579-4585
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	GENE-REGULATION ; TRANSLATIONAL REPRESSION ; TARGET PREDICTIONS
Subject RIV	EE - Microbiology, Virology
R&D Projects	GA310/07/1009 GA ČR - Czech Science Foundation (CSF)
	GA303/09/0475 GA ČR - Czech Science Foundation (CSF)
	IAA500200716 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000280922400011
DOI	10.1093/nar/gkq220
Annotation	A numerical model of miRNAmediated mRNA downregulation and its application to analysis of temporal microarray data of HepG2 cells transfected with miRNA-124a. Using the model analysis revealed a novel mechanism of mRNA accumulation control by miRNA, predicting that specific mRNAs are controlled in a digital, switch-like manner
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1