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Rapid effector function of circulating CD4+T cells specific for immunodominant regions of the conserved serine/threonine kinase found in Streptococcus pneumoniae (StkP) in healthy adults
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SYSNO ASEP 0351523 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Rapid effector function of circulating CD4+T cells specific for immunodominant regions of the conserved serine/threonine kinase found in Streptococcus pneumoniae (StkP) in healthy adults Author(s) Aslam, A. (GB)
Mason, A. (GB)
Zemenides, S. (GB)
Chan, H. (GB)
Nováková, Linda (MBU-M) RID
Branny, Pavel (MBU-M) RID, ORCID
Finn, A. (GB)
Chapel, H. (GB)
Ogg, G. S. (GB)Source Title FEMS Immunology and Medical Microbiology - ISSN 0928-8244
Roč. 60, č. 2 (2010), s. 113-122Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords epitopes ; pneumococcus ; ELISpot Subject RIV EE - Microbiology, Virology R&D Projects GP204/07/P082 GA ČR - Czech Science Foundation (CSF) GA204/08/0783 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000282810600002 DOI 10.1111/j.1574-695X.2010.00724.x Annotation This is the first study that has identified T-cell responses to peptides derived from a protein (StkP) from S. pneumoniae and has shown that in healthy adults, specific T cells have rapid IFN-g production compatible with effector cell differentiation. The use of such T-cell epitopes will aid in the future monitoring of T-cell responses to both S. pneumoniae infection and vaccination in humans Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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