Number of the records: 1

RTX proteins: a highly diverse family secreted by a common mechanism

SYSNO ASEP	0351522
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	RTX proteins: a highly diverse family secreted by a common mechanism
Author(s)	Linhartová, Irena (MBU-M)_{RID, ORCID} Bumba, Ladislav (MBU-M)_{RID, ORCID} Mašín, Jiří (MBU-M)_{RID, ORCID} Basler, Marek (MBU-M) Osička, Radim (MBU-M)_{RID, ORCID} Kamanová, Jana (MBU-M)_{ORCID, RID} Procházková, Kateřina (MBU-M) Adkins, Irena (MBU-M) Hejnová-Holubová, Jana (MBU-M)_RID Sadílková, Lenka (MBU-M) Morová, Jana (MBU-M) Šebo, Peter (MBU-M)_{RID, ORCID}
Source Title	FEMS Microbiology Reviews. - : Oxford University Press - ISSN 0168-6445 Roč. 34, č. 6 (2010), s. 1076-1112
Number of pages	37 s.
Language	eng - English
Country	US - United States
Keywords	bacterial toxin ; type I secretion system ; RTX locus
Subject RIV	EE - Microbiology, Virology
R&D Projects	IAA500200914 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	2B06161 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	KAN200520702 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA310/08/0447 GA ČR - Czech Science Foundation (CSF)
	GP310/09/P582 GA ČR - Czech Science Foundation (CSF)
	GP310/07/P115 GA ČR - Czech Science Foundation (CSF)
	GP204/07/P105 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z50520701 - BTO-N (2007-2013)
UT WOS	000282812600007
DOI	10.1111/j.1574-6976.2010.00231.x
Annotation	Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export across the bacterial envelope via the type I secretion system and the characteristic, typically nonapeptide, glycine- and aspartate-rich repeats binding Ca ions. In this review, we summarize the current state of knowledge on the organization of rtx loci and on the biological and biochemical activities of therein encoded proteins. Applying several types of bioinformatic screens on the steadily growing set of sequenced bacterial genomes, over 1000 RTX family members were detected, with the biological functions of most of them remaining to be characterized
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1