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Do we need new antibiotics? The search for new targets and new compounds
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SYSNO ASEP 0351521 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Do we need new antibiotics? The search for new targets and new compounds Author(s) Spížek, Jaroslav (MBU-M)
Novotná, Jitka (MBU-M)
Řezanka, Tomáš (MBU-M) ORCID
Demain, L. A. (US)Source Title Journal of Industrial Microbiology & Biotechnology - ISSN 1367-5435
Roč. 37, č. 12 (2010), s. 1241-1248Number of pages 8 s. Language eng - English Country DE - Germany Keywords Antibiotics ; Infectious diseases ; Antibiotic resistance Subject RIV EE - Microbiology, Virology CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000284373300005 DOI 10.1007/s10295-010-0849-8 Annotation Resistance to antibiotics and other antimicrobial compounds continues to increase. There are several possibilities for protection against pathogenic microorganisms, for instance, preparation of new vaccines against resistant bacterial strains, use of specific bacteriophages, and searching for new antibiotics. The antibiotic search includes: (1) looking for new antibiotics from nontraditional or less traditional sources, (2) sequencing microbial genomes with the aim of finding genes specifying biosynthesis of antibiotics, (3) analyzing DNA from the environment (metagenomics), (4) reexamining forgotten natural compounds and products of their transformations, and (5) investigating new antibiotic targets in pathogenic bacteria Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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