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Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling
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SYSNO ASEP 0351450 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling Author(s) Nencka, Radim (UOCHB-X) RID, ORCID
Sinnaeve, D. (BE)
Karalic, I. (BE)
Martins, J. C. (BE)
Calenbergh, Van S. (BE)Number of authors 5 Source Title Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
Roč. 8, č. 22 (2010), s. 5234-5246Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords ligand-free ; Suzuki-Miyaura cross-coupling ; phosphonate Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000283602000027 DOI 10.1039/c0ob00061b Annotation An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki–Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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