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Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

SYSNO ASEP	0351340
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
Author(s)	Schulte, G. (SE) Schambony, A. (DE) Bryja, Vítězslav (BFU-R)_{RID, ORCID}
Number of authors	3
Source Title	British Journal of Pharmacology. - : Wiley - ISSN 0007-1188 Roč. 159, č. 5 (2010), s. 1051-1058
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	beta-arrestin ; Wnt signaling ; dishevelled
Subject RIV	BO - Biophysics
R&D Projects	GC204/09/J030 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000275402000007
DOI	10.1111/j.1476-5381.2009.00466.x
Annotation	Beta-arrestins were originally identified as negative regulators of G protein-coupled receptor signalling, which can also serve as intracellular scaffolds and signalling intermediates. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signalling. Current findings implicates beta-arrestin as a determinant of WNT signalling specificity, a mediator of WNT/FZD desensitization and a regulator of signalling compartmentation.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1