Number of the records: 1

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

SYSNO ASEP	0351336
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Wnt2 regulates progenitor proliferation in the developing ventral midbrain
Author(s)	Sousa, K.M. (SE) Villaescusa, J.C. (SE) Čajánek, L. (SE) Ondr, J.K. (US) Castelo-Branco, G. (SE) Hofstra, W. (SE) Bryja, Vítězslav (BFU-R)_{RID, ORCID} Palmberg, C. (SE) Bergman, T. (SE) Wainwright, B. (AU) Lang, R.A. (US) Arenas, E. (SE)
Number of authors	12
Source Title	Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258 Roč. 285, č. 10 (2010), s. 7246-7253
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	Wnt2 ; ventral midbrain ; dopaminergic neuron
Subject RIV	BO - Biophysics
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000275415600037
DOI	10.1074/jbc.M109.079822
Annotation	In this study, we perform the first purification and signaling analysis of Wnt2 and define the function of Wnt2 in ventral midbrain precursor cultures, as well as in Wnt2-null mice in vivo. Collectively, our observations identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1