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Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity
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SYSNO ASEP 0351324 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity Author(s) Niederhafner, Petr (UOCHB-X) ORCID
Bednárová, Lucie (UOCHB-X) RID, ORCID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Šafařík, Martin (UOCHB-X) ORCID
Ehala, Sille (UOCHB-X) RID, ORCID
Ježek, Jan (UOCHB-X) RID
Borovičková, Lenka (UOCHB-X)
Fučík, Vladimír (UOCHB-X) RID
Čeřovský, Václav (UOCHB-X) RID, ORCID
Slaninová, Jiřina (UOCHB-X)Number of authors 10 Source Title Amino Acids. - : Springer - ISSN 0939-4451
Roč. 39, č. 5 (2010), s. 1553-1561Number of pages 9 s. Language eng - English Country AT - Austria Keywords melectin ; antibacterial peptides ; dendrimers ; hemolytic activity Subject RIV CC - Organic Chemistry R&D Projects GA203/03/1362 GA ČR - Czech Science Foundation (CSF) GA203/09/1919 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000283502900044 DOI 10.1007/s00726-010-0626-z Annotation The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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